Tag: 广州不准不开心网

Torpids row on come hell or high water

first_imgIt was a tense day for those at the Head of the River yesterday.While Christ Church men held their lead, fending off Pembroke’s advances with a more comfortable gap than Wednesday’s close finish, the Magdalen boys were in hot pursuit. The Headship remains up for grabs.Magdalen women have also been on top form, closing the gap with St Catherine’s earlier in the afternoon.After a long struggle up the division, their bump with Christ Church on Wednesday put headship in the Magdalen girls’ sights, and they will be upping the pressure on St Catz this afternoon.Yesterday, Magdalen were just a hair’s-width away as the klaxon went and St Catz were saved by the bell. Not so lucky were the four other boats who were bumped in time, seeing Wadham, New, SEH and Balliol move on up the division.The klaxon had been rung after a Hilda’s rower caught an ejector crab and was propelled into the water right in front of Balliol’s boat. St Catz cannot rely on that sort of luck to keep their place in the lead. The competition so far has also seen impressive form from both St John’s and Hertford men. Having both moved up a position on Wednesday, Thursday saw John’s bump New within the first 35 seconds of the race, Hertford taking Exeter seconds later.Balliol will have to watch out today with John’s right behind them.last_img read more

Organs-on-chips evaluate therapies for lethal radiation exposure

first_imgA team at the Wyss Institute for Biologically Inspired Engineering at Harvard University has received a $5.6 million grant from the United States Food and Drug Administration (FDA) to use its organs-on-chips technology to test human physiological responses to radiation and evaluate drugs designed to counter those effects. The effort will also be supported by a team in the vascular biology program at Children’s Hospital Boston.The multiyear project will investigate whether organs-on-chips — tiny, microfluidic devices that are lined by living human cells and mimic complex organ physiology — can be used instead of animals to evaluate the efficacy and safety of medical treatments for radiation sickness, or acute radiation syndrome (ARS). Animal models often fail to accurately predict human responses, and human subjects cannot be tested with exposure to lethal radiation.ARS occurs when the body receives a high dose of radiation, usually over a short period of time. Symptoms range from loss of appetite, fatigue, fever, nausea, vomiting, and diarrhea to seizures, coma, and death. The project is part of the FDA’s Medical Countermeasures Initiative (MCMi), which it launched in 2010.“One of the fundamental goals of the MCMi is to ensure that we are prepared to respond effectively to acts of terrorism that may involve radiological or nuclear attacks, and to incidents such as the Fukushima nuclear disaster in Japan in 2011,” said Luciana Borio, head of the FDA program. “We have a lot to learn about the human physiological response to radiation, and are excited to explore the potential of the Wyss Institute’s novel human organs-on-chips in filling that knowledge gap in a safe and cost-effective way.”,Combining microfabrication techniques with modern tissue engineering, lung-on-a-chip offers a new in vitro approach to drug screening by mimicking the complicated mechanical and biochemical behaviors of a human lung. This extended version of the video includes Wyss Institute findings when its researchers mimicked pulmonary edema-on-the-chip.[/gz_video]Earlier this year the institute’s lung-on-a-chip received the 3Rs prize from the U.K.’s National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs). The award followed a landmark publication in Science Translational Medicine demonstrating the team’s success using the lung on a chip to model human pulmonary edema (commonly known as fluid on the lungs) and to test potential new drug therapies under development.“We currently have over 10 different organs-on-chips in development, and are excited to work with the FDA to explore a new way to rapidly identify radiation countermeasures without having to rely on animal studies,” said Wyss Institute Founding Director Donald Ingber, who leads the organs-on-chips effort at the institute.The FDA-funded project will study three organs on chips. The three devices mimic the structure and physiology of human bone marrow, gut, and lung. These organ systems are the most susceptible to the toxic effects of radiation in humans, because of exposure to airborne particulates in the case of the lung, and extremely high cell turnover rates in the cases of the gut and bone marrow.“Our organs on chips enable us to investigate how specific human cell types and organ systems respond to radiation — something very difficult or impossible to mimic in animal studies,” said Wyss senior staff scientist Anthony Bahinski, who is helping lead the project. The effects of radiation and organ-level responses to potential radiation therapies can be observed in real time; the microdevices, about the size of a memory stick, are made of a clear, flexible polymer and can be attached to sophisticated imaging equipment.The lung-on-a-chip re-creates the way the human lung physically expands and retracts when breathing, and the gut on a chip mimics the peristaltic motions of the gut. This ability to replicate the physical microenvironment of living organs enables the organs on chips to recapitulate functions with a fidelity not possible in conventional culture systems, and it represents a key advantage of these novel bioinspired microtechnologies.The bone marrow chip employs a unique approach to organ-chip design in which the team uses tissue engineering to form a whole bone with an intact marrow in vivo — and then surgically removes it and places it under microfluidic conditions in the laboratory. From there it can undergo testing in response to radiation and radiation therapies.“We should have a much better understanding of how our bones, intestines, and lungs respond physiologically to radiation and radiation therapies at the conclusion of this project,” Bahinski said.In addition to the FDA, the Wyss Institute acknowledges support that led to the development of the organs-on-chips technology from the Defense Advanced Research Projects Agency and the National Institutes of Health.last_img read more

Bills QB Allen Stays Busy Despite Pandemic Restrictions

first_imgBuffalo Bills quarterback Josh Allen (17) Buffalo Bills vs. Miami Dolphins, October 20, 2019 at New Era Field. Photo by Bill Wippert/BuffaloBills.com.BUFFALO — Josh Allen has hardly spent this coronavirus pandemic-altered offseason in self-isolation.The Buffalo Bills quarterback, instead, kept himself busy in seeking advice from Peyton Manning and Brett Favre on Zoom calls, to gathering his teammates together for workouts on both coasts.It’s all been done with an intent to continue developing into a team leader entering his third season, and smooth the inconsistencies that have hampered Allen and the offense’s production.What fuels Allen is the still stinging memory of his up-then-down performance in a 22-19 overtime loss to Houston in an AFC wild-card playoff, in which the Bills squandered a 16-0 third-quarter lead. “I was talking about it last night, so I’m definitely not over it,” Allen during a Zoom conference call with Buffalo-area reporters Thursday.He was efficient in the first half by going 13 of 20 for 131 yards and catching a touchdown pass, before unraveling in going 11 of 26 for 133 yards and a lost fumble the rest of the way.“I know that we had opportunities to win that game,” he said. “That’s something that continues to drive me in knowing I could’ve played better and I could’ve done more, and I could’ve eliminated a mistake here or there that could’ve been super easy to eliminate and given us a better chance to win that game.”It was a performance which encapsulated the best and worst of Allen, the Bills 2018 first-round pick, who has yet to shed his pre-draft reputation of being a strong-armed, but raw product with accuracy issues.“I’ve got personal goals set out for myself,” Allen said, noting his 11-0 career record when completing 60% or more of passes in games he starts and finishes.“So I think that’s the goal every game to at least hit 60%,” he said. “I’m not going to try to force things and I’m not going to be Captain Checkdown either.”The test for Allen this offseason has been finding ways to improve without the benefit of on-field practices, with the pandemic wiping out the NFL’s entire spring schedule.He began by seeking advice from former Dallas Cowboys quarterback Tony Romo, whom he met at the Super Bowl. It continued with offensive coordinator Brian Daboll inviting Favre — Allen’s childhood idol — and Manning to provide tips during the Bills’ virtual quarterbacks meetings.Allen then took it upon himself to organize a workout with Bills offensive rookie draft picks in California in early May, followed by bringing together 19 offensive players for workouts in Miami a few weeks later.Allen’s take-charge approach drew praise from Daboll and coach Sean McDermott.“He’s our quarterback, but you can’t force leadership. You can improve it, you can learn about it. You can grow from it,” Daboll said. “But Josh has innate leadership qualities that guys gravitate toward, and he understands his role on the team.”Added McDermott: “It’s a critical step that he took it upon himself and his own initiative to put this together.”The Miami workouts were particularly important because they marked the first time Allen was able practice throws with receiver Stefon Diggs, the dynamic threat acquired in a trade with Minnesota in March.“It was very, very awesome to see just the amount of detail he puts into his craft, how communicative he was, how willing he was to learn,” Allen said of Diggs, noting they first got to know each other from afar by playing video games. “He’s such an explosive player and a great player, and he’s going to add a lot to our offense.”Scoring more points was general manager Brandon Beane’s objective behind acquiring Diggs, who joins a well-established group of receivers rounded out by John Brown and Cole Beasley. Despite a 10-6 finish, the Bills scored 21 or more points just six times and ranked 23rd in the NFL in scoring and 24th in yards offense.Allen made significant strides from his rookie season by showing poise and patience in the pocket, rather than sprinting off at the first sign of pressure. He did benefit from playing in front of a sturdier and rebuilt line, which featured four newcomers, including center Mitch Morse.Allen doubled his touchdowns passing total to 20 and threw only nine interceptions (down from 12 the previous year). Though he enjoyed a six-point jump in completing 58.8% of his passes, Allen still ranked last among NFL starters.Allen particularly credited Romo for providing tips that have improved his throwing motion, which he saw pay off during the Miami workouts.“I felt like it’s the best I’ve ever thrown,” Allen said, noting the next step is reproducing that motion once the Bills can begin practicing. “I feel good where I’m at right now.” Share:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window)last_img read more

New Jersey man wins Wilbur’s Run

first_img Like he did in the ’60s, Noel Paul Stookey sings out in troubling times – December 27, 2017 Wallack, who hails from Windsor, N.J., bested a field of more than 100 runners and walkers with his winning time of 18 minutes and 2 seconds over the five-kilometer course.Finishing as runner-up in 18:20 was Frank King of Ellsworth, who took first among runners ages 13-19.This is placeholder textThis is placeholder textThe first woman to finish was Katie Jones of Boston, who placed 16th overall with a time of 22:29.Bella Cimeno of Blue Hill was the women’s runner-up, finishing 19th overall and first among runners ages 13-19 with her time of 22:48.The event, which drew its inspiration from E.B. White’s “Charlotte’s Web,” was a fundraiser to support wellness and fitness programming at Blue Hill Memorial Hospital and the Blue Hill branch of the Down East Family YMCA.Other male and female age group winners:Ages 20-29 – Christopher Heel of Mount Desert, 12th overall in 21:32, and Angelica Carr of Mount Desert, 24th overall in 23:15.Ages 30-39 – Chris Veilleux of Brighton, Mass., sixth overall in 19:15, and Rylan Okie of Boston, 32nd overall in 24:42.Ages 40-49 – Rob Shea of Ellsworth, third overall in 19:00, and Tricia Brown of Cherryfield, 20th overall in 22:55.Ages 50-59 – Mark Collinsworth of Bath, N.Y., 17th overall in 22:36, and Susan Brooks of Benton, 29th overall in 24:28.Ages 60-69 – William MacDowell of Blue Hill, 43rd overall in 25:49, and Isabel Karl of Blue Hill, 61st overall in 28:01.Other runners placing among the top 15:Phil LeBreton of Bucksport, fourth in 19:14.Tate Yoder of Penobscot, seventh in 20:20.Evan Merchant of Beals, eighth in 20:59.Matt Mattson of Blue Hill, ninth in 21:21.Jeremiah Scheff of Blue Hill, 10th in 21:29.Bill Schade of Marlboro, Mass., 11th in 21:30.Caden Mattson of Blue Hill, 13h in 21:37.Max Mattson of Blue Hill, 14h in 21:43.Mike Mittner of Surry, 15h in 22:00. BLUE HILL — Doug Wallack was visiting in Brooklin last week and decided to compete in the second annual Wilbur’s Run on Saturday at the Blue Hill Fair. Latest Posts Hugh BowdenExecutive EditorHugh writes editorials, covers Hancock County sports and helps out where needed in The American’s editorial department. When he’s not on the sidelines, he enjoys playing jazz and tennis. [email protected] Latest posts by Hugh Bowden (see all) GSA surges in 4th to win Northern Maine title – February 26, 2017 Bio Is this the kind of government we deserve? – July 10, 2017last_img read more

Mark Your Calendar for Olympia Third Thursday, February 21, 2019

first_imgFacebook21Tweet0Pin0Submitted by Olympia Downtown AllianceDowntown Olympia’s Third Thursdays are a community celebration of local culture, art, food, music, and unique shopping experiences.Participating businesses give special Third Thursday discounts, extend happy hours and hold artist receptions. The streets are all set to live music from buskers and the mood is vibrant. Whether you make it a date night, a fun outing with friends or a family adventure, there is so much to discover downtown.A fun element of each Third Thursday is the Challenge Game! Stop by our info the corner of 4th & Washington and pick up a Challenge Game or pick up the Challenge Game at a Third Thursday business. Participants can visit each business to get another letter to solve the phrase of the month. Complete the phrase first and win! We love to see so many groups of friends and families return month after month to participate in the Challenge Game.Here are a few businesses that are participating this month:Three Magnets — Mention you’re in for Third Thursday and receive three 5 oz beer tasters!Budd Bay Bargains Too! Grand Opening at the Estate Store – The Estate Store is expanding its clothing section with a large selection of vintage and gently worn stylish clothing!Captain Little – Join Captain Little for sips & treats, and enjoy a night in community with downtown Olympia!Dillinger’s Cocktail Kitchen – Come imbibe on Third Thursday with Happy Hour extended until 8 p.m.!Batdorf & Bronson Coffee RoastersGallery BoomBittersweet ChocolatesHoly Lamb OrganicsRadiance Herbs & MassageCompass RoseBelleza RopaVoyeur Cafe & LoungeWHAT: Olympia’s Third ThursdayWHEN: Thursday, February 21, 2019. The Olympia Downtown Alliance will host an info booth, located in the US Bank parking lot from 4 p.m. – 7 p.m.WHERE: Olympia’s Downtown.WHO: Presented by Providence Health Services and brought to the community by the Olympia Downtown Alliance and Mixx96FM. For more information about Third Thursday events, contact Brit Kramer, (360) 481-5010 or [email protected] For more information about Olympia Downtown Alliance, contact Todd Cutts, (360) 357-8948 or [email protected] you to our Challenge Game sponsor, HomeStreet Bank!Thank you to our Third Thursday presenting sponsor, Providence!About the Olympia Downtown AllianceThe Olympia Downtown Alliance does not discriminate in employment or the delivery of services and resources on the basis of age, sex, race, creed, color, sexual orientation, or national origin, or the presence of any physical, mental or sensory disability.last_img read more

Holmdel Historic Cemetery Is Getting A Facelift

first_imgStory and photos by Joseph SapiaHOLMDEL – At the Beau Ridge residential development on Laurel Avenue, one can park a car and walk across a footbridge over a stream, only to find a small hill with a cemetery, surrounded by condominiums.It is one of various family burial grounds one can find in Central Jersey, where the farm that once sat in place is now developed land, with the cemetery still, sometimes barely, hanging on. This one is the Hendricks Family Burial Ground, where members of among the township’s oldest families – Hendricks or Hendricksons, depending on the variation of the surname – were buried from about 1700 to 1950.Now, with the warmer weather here, work is continuing on restoring the 1-acre cemetery, where it is believed 99 are buried, but with only 63 graves that are marked.What happened to the cemetery was a combination of the land being sold by the Hendrickson family in about 1985, when it was then a horse farm, for the Beau Ridge development; the cemetery falling into disrepair; and, in 2010, the governing body of Beau Ridge residents hiring a company to clear the cemetery, according to Art Rittenhouse of Sayreville, one of the family members.The latter led to a lawsuit by the Hendricks and Hendrickson Family Association of New Jersey against Beau Ridge and various parties, Rittenhouse said. The litigation was settled in the last several months, for a confidential amount – “enough money” to rehabilitate the cemetery, Rittenhouse said.“I’m glad the destruction has stopped, the settlement made and the restoration started,” said Robert Hendrickson of Wall. Rittenhouse said it was “probably in the early ‘90s” the cemetery began falling into disrepair. In 1999, the family had a reunion and visited the cemetery, which “was a mess,” according to Hendrickson.Over the months, the cemetery has been cleaned, which remains a work in progress. In the last year or so, a wooden fence was put up as part of a Boy Scouts Eagle project, for example.The rehabilitation also includes clearing out vegetation, repositioning old gravestones, and putting in new, but historic-looking, gravestones.“We’re hoping for possibly September to have a rededication (of the cemetery),” Rittenhouse said.Lois Hendrickson Ketcham of Wall is a Hendricks-Hendrickson family member who does family history.“Doing family history, I’m proud how the family has been here from the beginning,” Ketcham said. “I don’t want to forget the past.”Although there is room for more burials, “we’re not planning on putting” more graves in, Rittenhouse said.Rittenhouse said it appears his roots through his maternal side go back to William Hendrickson, a founder of Holmdel. William and his brother, Daniel, another township founder, were buried at the cemetery in the early 1700s.Earlier this year, various family members visited cemetery together.“I’m very happy we’re all here today,” said Claire Hendrickson Waltsak of Wall. “I feel I’m made up of all these people buried here.“We’re still here,” Waltsak said. “I hope I make my founders proud.”last_img read more