Tag: 宁波鼓楼很多鸡

STS9 Welcomes GRiZ In Birmingham For “Frequency” Encore [Watch]

first_imgSTS9 celebrated their “Halloween Launch Off Party” last night with GRiZ, Haywyre, and The Geek x Vrv at Oak Mountain Amphitheatre in Birmingham, AL. With Sound Tribe taking center stage, they made sure to bring all the jams and an “Out of this World” transition to “Rent” finale. The electronic jam pioneers welcomed out saxophonist GRiZ for a “Frequency” encore, marking a special moment for all those in attendance who got to witness the first-time collaboration.GRiZ shared a recap video, which you can watch below:Additionally, some fans were quick to record the epic collaboration. Thanks to Instagram users @zchflmng and @y2jim, you can peep a little more of last night’s action. STS9 @ Oak Mountain Amphitheatre in Birmingham, Alabama 10/28/16:Set: March>>Moonsocket, Love Don’t Terrorize, To The World, Circus, Sun,Moon,&Stars>Inspire Strikes Back, Out Of This World*>>RentEncore: Frequency 2>3 (w/ GRiZ)*instantly jam[Photo Credit to Jim Shepherd, Setlist via The Church of STS9 Facebook]last_img read more

How Zika infects the growing brain

first_img Related “We knew that organoids are great models for microcephaly and other conditions that show up very early in development and have a very pronounced effect,” said Kaykas. “For the first few months, the organoids do a really good job in recapitulating normal brain development.”Historically, human NPCs have been difficult to study in the lab because it was impossible to obtain samples without damaging brain tissue. With the advancements in induced pluripotent stem cell (iPS cell) technology, a cell reprogramming process that allows researchers to coax any cell back into a stem cell-like state, researchers can now generate these previously inaccessible human tissues in a petri dish.The team was able to produce human iPS cells and then, using gene-editing technology, modify the cells to knock out AXL expression, said Michael Wells, a Harvard postdoctoral researcher and co-first author. The scientists pushed the iPS cells to become NPCs, building the 2-D and 3-D models that were infected with Zika.The Harvard/NIBR collaborators started working with the virus in mid-April. The unusual speed of the research reflects the urgency of the challenge, as the Zika virus has spread to more than 70 countries and territories.“At the genesis of the project, my wife was pregnant,” Eggan remarked. “One can’t read the newspapers without being concerned.”The collaboration grew out of interactions at the Broad Institute of MIT and Harvard’s Stanley Center for Psychiatric Research, where Eggan directs the stem cell program. His lab already had developed cell culture systems for studying NPCs in motor neuron and psychiatric diseases. The team at Novartis had created brain organoids for research on tuberous sclerosis complex and other genetic neural disorders.“Zika seemed to be a big issue where we could have an impact, and we all shared that interest,” Eggan said. “It’s been great to have this public-private collaboration.”The researchers are studying other receptor proteins that may be open to Zika infection, in hopes that their basic research eventually will aid the quest to develop vaccines or other drugs that defend against the virus.This research was funded by the Stanley Center for Psychiatric Research and the Harvard Stem Cell Institute. Paper disc can quickly detect Zika virus in the field Around the world, hundreds of women infected with the Zika virus have given birth to children suffering from microcephaly or other brain defects, as the virus attacks key cells responsible for generating neurons and building the brain as the embryo develops. Studies have suggested that Zika enters these cells, called neural progenitor cells (NPCs), by grabbing onto a specific protein called AXL on the cell surface. Now, scientists at the Harvard Stem Cell Institute (HSCI) and Novartis have shown that this is not the only route of infection.The scientists demonstrated that Zika infected NPCs even when the cells did not produce the AXL surface receptor protein that is widely thought to be the main vehicle of entry for the virus.“Our finding really recalibrates this field of research because it tells us we still have to go and find out how Zika is getting into these cells,” said Kevin Eggan, principal faculty member at HSCI, professor of stem cell and regenerative biology at Harvard University and co-corresponding author on a research paper in the journal Cell Stem Cell.“It’s very important for the research community to learn that targeting the AXL protein alone will not defend against Zika,” said Ajamete Kaykas, co-corresponding author and a senior investigator in neuroscience at the Novartis Institutes for BioMedical Research (NIBR).Previous studies have shown that blocking expression of the AXL receptor protein defends against the virus in a number of human cell types. Given that the protein is highly expressed on the surface of NPCs, many labs have been working on the hypothesis that AXL is the entry point for Zika in the developing brain.“We were thinking that the knocked-out NPCs devoid of AXL wouldn’t get infected,” said Max Salick, a NIBR postdoctoral researcher and co-first author on the paper. “But we saw these cells getting infected just as much as normal cells.”Working in a facility dedicated to infectious disease research, the scientists exposed two-dimensional cell cultures of AXL-knockout human NPCs to the Zika virus. They followed up by exposing 3-D mini-brain “organoids” containing such NPCs to the virus. In both cases, cells clearly displayed Zika infection. This finding was supported by an earlier study that knocked out AXL in the brains of mice. Inexpensive method could slow spread of outbreak, future pandemic diseases last_img read more

HJC continues awards for IMCA national champions, special events drivers

first_imgCERRITOS, Calif. (May 6) – Awards for IMCA national champions and special events competitors have been renewed for a sixth season by HJC Motor­sports.The helmet and accessories manufacturer and retailer, located in Cerritos, Calif., gives SA2010 AR-10 helmets to national champions in the IMCA Xtreme Motor Sports Modified, IMCA Late Model, IMCA Eagle Motorsports RaceSaver Sprint Car, IMCA Sunoco Stock Car, IMCA Sunoco Hobby Stock, Karl Chevrolet Northern SportMod, Scoggin-Dickey Parts Center Southern SportMod and Mach-1 Sport Compact divisions.Helmets will be presented during the national awards banquet in November.A designated place finisher at each of 30 Modified special events will receive $50 product certificates, which will be mailed from the IMCA home office after official race results are received from the track.Information about helmets and other products available from HJC is available by calling 562 407-2186, on Facebook and at the www.hjc-motorsports.com website.“With the addition of the SA2015 helmet certification this season, everyone should check the date of their current helmet,” recommended IMCA Marketing Director Kevin Yoder. “Anything rated SA2000 and older is not legal in competition and if you are in the market for new headgear it would be worth checking out what HJC has to offer.”last_img read more