Time: 5:30 PM State Senator Jim Tomes, District 49 State Senator Vaneta Becker, District 50 State Representative Matt Hostettler, District 64State Representative Wendy McNamara, District 76State Representative Holli Sullivan, District 78 EVSC Board of School Trustees Meeting- Location: Room 301, Civic Center Complex 1 NW Martin Luther King Blvd, Evansville Time: 5:30 PM County Commissioners County Council Meeting- Date: Wednesday, December 4, 2019 January 8, 2020 First day to file a Declaration of Candidacy for 2020 Primary December 10 (3:00 pm) January 31, 2020Congress of Counties Location: Room 301, Civic Center Complex 1 NW Martin Luther King Blvd, Evansville Time: 11:30 AMLocation: GOP Headquarters815 John Street, EvansvilleMeetings are open to all Vanderburgh County Precinct Committeemen December 14 (10:00 am)Bill of Rights Celebration For more information visit December 16 (5:30 pm)City Council Meeting Location: Room 301, Civic Center Complex 1 NW Martin Luther King Blvd, Evansville County Commission Meeting- Date: Tuesday, December 10, 2019 Date: December 9, 2019 Click to watch President Trump Deliver Remarks to the TroopsRead Remarks by President Trump to Troops at Bagram Airfield | Bagram, Afghanistan December 9 (5:30 pm)EVSC Board of Trustees Meeting VCRP Central Committee Meeting – Wednesday, December 11, 2019 Time: 3:30 PM Central Committee:Wayne Parke, ChairmanMary Jo Kaiser, Political DirectorDottie Thomas, Vice ChairmanLon Walters, Secretary Kevin Harrison, Editor Wednesday, January 8, 2020 is the first day a declaration of candidacy for major political party primary nomination (or election as a Republican Party precinct committeeman, or state convention delegate of either major party at the primary) may be filed. It is also the first day a major party primary candidate for President or Governor may file a petition of nomination with a county voter registration office for verification of petition signatures. Refer to the Indiana Secretary of State Election Division’s Candidate Information web page for candidate forms and additional information.Candidates for precinct committeeman must be a Qualified Elector of the precinct and a Qualified Primary Republican (or obtain authorization from the County Chairman). Candidates for precinct committeeman must file a CAN-37 form with the county clerk between Wednesday January 8, 2020 and noon Friday, February 7, 2020. Form CAN-37 can be found on the Secretary of State Election Division’s Candidate Information web page.Republican State Convention Delegate Candidates must be a resident of the Election District and a Qualified Primary Republican. A declaration of candidacy for election as a state convention delegate (form CAN-37) must be filed with the county election board no earlier than January 8, 2020 and no later than noon February 7, 2020. All delegates will be assessed a $100 fee payable to the Indiana Republican State Committee to help defer State Convention costs.Contact VCRP Political Director Mary Jo Kaiser at [email protected] or 812-425-8207 for more information. Time: 3:00 PM Farley Smith, Treasurer Location: Board Room, EVSC Administration Building 951 Walnut St., Evansville For more information visitCity Council (Click Above ) City Council Meeting- Date: Monday, December 16, 2019 scvasvasvasv County Council Meeting News and Upcoming Events for December 3, 2019 January 18, 2020 VCRP Monthly Breakfast December VCRP Breakfast CANCELLEDThe VCRP will not hold a Breakfast Meeting for the month of December.The next scheduled Breakfast will be Saturday January 18, 2020. Mark Your calendar CLICK on event for more information scvasvasvasv President Trump Spends Thanksgiving with the Troops- scvasvasvasv County Commission Meeting The 2020 Congress of Counties is a two-day training conference for Republican Party leaders, candidates and grassroots activists. This year’s Congress of Counties is scheduled for January 31 – February 1 in downtown Indianapolis at the Crowne Plaza Hotel. Registration will be $100 per person. The full conference line-up — including break-out training sessions and special events — will be announced soon! For more information and to register click HERE. First day of declaration of candidacy for 2020 Primary Election is Wednesday, January 8, 2020 For more information visitCounty Council Stay in touch with GOP state legislators representing our area by clicking the links below. December 4 (3:30 pm) FacebookTwitterCopy LinkEmail
Connecticut-based extreme funk rockers Kung Fu played Buffalo Iron Works in Buffalo, NY last night, with Mister F in tow as support. The group continued their recent affinity for Steely Dan, as they played cuts such as “Kid Charlemagne,” “Reelin’ In The Years” and “Bodhissatva.” They also debuted an absolute beast of a song called “Chop Suey” during the set as well.Take a listen to the track below, courtesy of SonicGardenPlaysDead:Kung Fu’s Fez Tour, in which they play one set of Kung Fu originals, and one set of Steely Dan, continues this evening in Detroit, then on to Chicago, as they make their way across the country to a multi-night run in Colorado, and much more. Check out a full schedule of Kung Fu tour dates here.Setlist: Kung Fu | Buffalo Iron Works | Buffalo, NY | 3/22/17Primetime Rib, Svendago > Daddy D, Chop Suey, Kid Charlemagne, Black Cow, Your Gold Teeth, The Fez > Green Earrings, Aja, Reelin’ In The Years, Peg, Bodhisattva*, My, Old School**, Gung HoE: Josie*w/ Scott Hannay of Mister F on keys**w/ Sarah Jane on vocals
Using a system that analyzes blood samples with unprecedented detail, a team led by Harvard Medical School (HMS) researchers at Massachusetts General Hospital (MGH) has developed the first “chemical snapshot” of the metabolic effects of exercise. Their findings, reported today’s edition of Science Translational Medicine, may improve understanding of the physiologic effects of exercise and lead to new treatments for cardiovascular disease and diabetes.“We found new metabolic signatures that clearly distinguish more-fit from less-fit individuals during exercise,” says Gregory Lewis, an HMS instructor based at the MGH Heart Center, the paper’s lead author. “These results have implications for the development of optimal training programs and improved assessment of cardiovascular fitness, as well as for the development of nutritional supplements to enhance exercise performance.”The beneficial health effects of exercise – including reducing the risk of heart disease, stroke and type 2 diabetes – are well known, but the biological mechanisms underlying those effects are unclear. Previous investigations of exercise-induced changes in metabolites – biological molecules produced in often-minute quantities – have focused on the few molecules measured by most hospital laboratories. Using a new mass-spectrometry-based system that profiles more than 200 metabolites at a time – developed in collaboration with colleagues from the Broad Institute of Harvard and MIT, led by Clary Clish, PhD – the MGH-based team analyzed blood samples taken from healthy participants before, immediately following, and one hour after exercise stress tests that were approximately 10 minutes long.Exercise-associated changes were seen in more than 20 metabolites, reflecting processing of sugars, fats and amino acids as fuels as well as the body’s utilization of ATP, the primary source of cellular energy. Several changes involved metabolic pathways not previously associated with exercise, including increases in niacinamide, a vitamin derivative known to enhance insulin release.Another experiment that analyzed samples taken from different vascular locations indicated that most metabolite changes were generated in the exercising muscles, although some appeared to arise throughout the body. In both experiments, several metabolite changes persisted 60 minutes after exercise had ceased.In an experiment designed to assess the effects of prolonged exercise, pre- and post-race samples were taken from 25 runners who completed the 2006 Boston Marathon. Extensive changes in several metabolites – some different from those produced by brief exercise – were seen in the post-race samples. Indicators of increased metabolism of fats, glucose and other carbohydrates rose in response to both brief and prolonged exercise, but in marathoners amino acid levels also fell significantly, reflecting their use of amino acids as fuel to maintain adequate glucose levels during extended exercise.The researchers also analyzed how these metabolite changes related to participants’ level of fitness – determined by peak oxygen uptake in the short-term experiments and by finishing times for the marathon runners. In both groups they found that several changes, including those reflecting increased fat metabolism, were more pronounced in participants who were more fit.Pursuing the hypothesis that metabolites which increase in response to exercise act on pathways involved in cellular respiration and glucose utilization, the investigators applied different combinations of metabolites to cultured muscle cells. They found that a combination of five molecules increased expression of nur77, a gene recently shown to regulate glucose levels and lipid metabolism, making it a possible treatment target for the combination of cardiovascular risk factors known as metabolic syndrome. The association of nur77 levels with exercise was supported by an experiment that found gene expression increased fivefold in the muscles of mice that had exercised for 30 minutes.“Our results have implications for development of both diagnostic testing to track and improve exercise performance and for interventions to reduce the effects of diabetes or heart disease by improving a patient’s metabolic ‘fingerprint’,” explains HMS associate profressor Robert Gerszten, MD, director of Clinical and Translational Research at the MGH Heart Center, the study’s senior author. “Improving the health of people with cardiovascular disease is our number one goal, but defining which metabolites become deficient and need to be replenished during exercise could also lead to the next generation of sports drinks that can help healthy individuals achieve their best exercise performance.”The study was supported by grants from the National Institutes of Health, the Donald W. Reynolds Foundation, Fondation Leducq, and the American Heart Association.Additional authors of the Science Translational Medicine paper are Laurie Farrell, Malissa Wood, MD, Maryann Martinovic, Susan Cheng, MD, Rahul Deo, MD, PhD, Aarti Asnani, MD, Marc Semigran, MD, and Thomas Wang, MD, MGH Heart Center; Eugene Rhee, MD, and David Systrom, MD, MGH Department of Medicine; Amanda Souza, Elaine Yang, Xu Shi, MD, Steven Carr, PhD, and Clary Clish, PhD, Broad Institute; Zoltan Arany, MD, and Glenn Rowe, PhD, Beth Israel Deaconess Medical Center; Elizabeth McCabe, MS, Framingham Heart Study; Frederick Roth, PhD, Harvard Medical School; Ramachandran Vasan, MD, Boston University School of Medicine; and Marc Sabatine, MD, Brigham and Women’s Hospital.