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Organs-on-chips evaluate therapies for lethal radiation exposure

first_imgA team at the Wyss Institute for Biologically Inspired Engineering at Harvard University has received a $5.6 million grant from the United States Food and Drug Administration (FDA) to use its organs-on-chips technology to test human physiological responses to radiation and evaluate drugs designed to counter those effects. The effort will also be supported by a team in the vascular biology program at Children’s Hospital Boston.The multiyear project will investigate whether organs-on-chips — tiny, microfluidic devices that are lined by living human cells and mimic complex organ physiology — can be used instead of animals to evaluate the efficacy and safety of medical treatments for radiation sickness, or acute radiation syndrome (ARS). Animal models often fail to accurately predict human responses, and human subjects cannot be tested with exposure to lethal radiation.ARS occurs when the body receives a high dose of radiation, usually over a short period of time. Symptoms range from loss of appetite, fatigue, fever, nausea, vomiting, and diarrhea to seizures, coma, and death. The project is part of the FDA’s Medical Countermeasures Initiative (MCMi), which it launched in 2010.“One of the fundamental goals of the MCMi is to ensure that we are prepared to respond effectively to acts of terrorism that may involve radiological or nuclear attacks, and to incidents such as the Fukushima nuclear disaster in Japan in 2011,” said Luciana Borio, head of the FDA program. “We have a lot to learn about the human physiological response to radiation, and are excited to explore the potential of the Wyss Institute’s novel human organs-on-chips in filling that knowledge gap in a safe and cost-effective way.”,Combining microfabrication techniques with modern tissue engineering, lung-on-a-chip offers a new in vitro approach to drug screening by mimicking the complicated mechanical and biochemical behaviors of a human lung. This extended version of the video includes Wyss Institute findings when its researchers mimicked pulmonary edema-on-the-chip.[/gz_video]Earlier this year the institute’s lung-on-a-chip received the 3Rs prize from the U.K.’s National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs). The award followed a landmark publication in Science Translational Medicine demonstrating the team’s success using the lung on a chip to model human pulmonary edema (commonly known as fluid on the lungs) and to test potential new drug therapies under development.“We currently have over 10 different organs-on-chips in development, and are excited to work with the FDA to explore a new way to rapidly identify radiation countermeasures without having to rely on animal studies,” said Wyss Institute Founding Director Donald Ingber, who leads the organs-on-chips effort at the institute.The FDA-funded project will study three organs on chips. The three devices mimic the structure and physiology of human bone marrow, gut, and lung. These organ systems are the most susceptible to the toxic effects of radiation in humans, because of exposure to airborne particulates in the case of the lung, and extremely high cell turnover rates in the cases of the gut and bone marrow.“Our organs on chips enable us to investigate how specific human cell types and organ systems respond to radiation — something very difficult or impossible to mimic in animal studies,” said Wyss senior staff scientist Anthony Bahinski, who is helping lead the project. The effects of radiation and organ-level responses to potential radiation therapies can be observed in real time; the microdevices, about the size of a memory stick, are made of a clear, flexible polymer and can be attached to sophisticated imaging equipment.The lung-on-a-chip re-creates the way the human lung physically expands and retracts when breathing, and the gut on a chip mimics the peristaltic motions of the gut. This ability to replicate the physical microenvironment of living organs enables the organs on chips to recapitulate functions with a fidelity not possible in conventional culture systems, and it represents a key advantage of these novel bioinspired microtechnologies.The bone marrow chip employs a unique approach to organ-chip design in which the team uses tissue engineering to form a whole bone with an intact marrow in vivo — and then surgically removes it and places it under microfluidic conditions in the laboratory. From there it can undergo testing in response to radiation and radiation therapies.“We should have a much better understanding of how our bones, intestines, and lungs respond physiologically to radiation and radiation therapies at the conclusion of this project,” Bahinski said.In addition to the FDA, the Wyss Institute acknowledges support that led to the development of the organs-on-chips technology from the Defense Advanced Research Projects Agency and the National Institutes of Health.last_img read more

John-Michael Girald joins The Bigelow Company

first_img“I am delighted to announce that John-Michael Girald has recently joined our firm,” said Peter R. Worrell, Managing Director of The Bigelow Company LLC. “Girald’s unique experience in having worked with both large corporate and entrepreneurial investment banking firms means that he will be able to bring a broad perspective of value-adding strategies to Bigelow’s clients. This meaningful addition to our professional staff further demonstrates Bigelow’s continuing commitment to bring the best industry talent to bear on our client opportunities.”Most recently, Girald was a Senior Analyst in the Philadelphia-based middle market investment banking practice of Legg Mason Wood Walker, Inc where in some ways similar to Bigelow, they specialize in assisting companies with acquisition and merger strategy and implementation. While at Legg Mason, Girald focused on client needs in all facets of corporate finance transactions, including initial public offerings, formulation of growth financing strategies, the private placement of debt and equity, and a strong emphasis on merger and acquisition transactions.Prior to his three years with Legg Mason, Girald earned his Bachelors degree in Finance from Villanova University, where he also minored in Management Information Systems. He is now a resident of Salem, MA.The Bigelow Company is best known for serving as private investment bankers to owner-managers of some of the most successful entrepreneurial companies in North America. Bigelow concentrates its resources exclusively on capturing sustainable enterprise value for its entrepreneurial clients.last_img read more

Tanduay stretches win streak to five, dispatches Racal

first_imgMarcosian mode: Duterte threatens to arrest water execs ‘one night’ McGregor blasts Cerrone in 40 seconds in UFC return “Every time he watches, we loses, so we just wanted to break that and also continue our momentum so that we’ll go home smiling,” said coach Lawrence Chongson said of the no-bearing game for the third-seed Tanduay.Von Tambeling led the Rhum Masters with 13 points, three rebounds, and two assists, while James Martinez got 12 markers and three dimes.FEATURED STORIESSPORTSEnd of his agony? SC rules in favor of Espinosa, orders promoter heirs to pay boxing legendSPORTSRedemption is sweet for Ginebra, Scottie ThompsonSPORTSMayweather beats Pacquiao, Canelo for ‘Fighter of the Decade’Emil Palma added 11 points, eight of which coming in the fourth quarter for Tanduay, as they fended off an upset-seeking Racal crew which got to as close as four, 74-70, with four minutes left to play.Paul Varilla also had 10 markers, six boards, and two assists in the conquest for the Rhum Masters. Indian national gunned down in Camarines Sur LeBron James scores 31 points, Lakers beat Rockets View comments LATEST STORIES Kawhi Leonard, Clippers rally to beat Pelicans ‘I’m out!’: PewDiePie releases last video before taking break from YouTube MOST READ Eric Kelly moves up to lightweight for Boku fight Racal suffered its third straight defeat, sixth in its last seven games, to wound up with a 3-6 slate, with a game against CEU on Tuesday remaining in its schedule.Allan Mangahas poured 14 points to lead his side in the losing effort.The Scores:TANDUAY 81 – Tambeling 13, Martinez 12, Palma 11, Varilla 10, Gaco 9, Sollano 7, Eguilos 4, Taganas 4, Vigil 4, Terso 3, Alvarez 2, Santos 2, Villamor 0.RACAL MOTORS 72 – Mangahas 14, Tallo 10, Cabrera 9, Pontejos 9, Lozada 8, Capacio 6, Faundo 4, Gomez 3, Ortuoste 3, Cortes 2, Grimaldo 2, Octubre 2, Apreku 0, Ayonayon 0.ADVERTISEMENT Emil Palma. PBA IMAGESTanduay continued to gain steam going into the 2017 PBA D-League Foundation Cup quarterfinals, nipping Racal Motors, 81-72 Thursday at Ynares Sports Arena in Pasig.With their fifth straight victory, the Rhum Masters ended their eliminations campaign with an 8-2 slate, while also giving team owner Bong Tan, who was in the audience, a win.ADVERTISEMENT End of his agony? SC rules in favor of Espinosa, orders promoter heirs to pay boxing legend OSG plea to revoke ABS-CBN franchise ‘a duplicitous move’ – Lacson 787 earthquakes recorded in 24 hours due to restive Taal Volcano Quarters: 21-16, 49-44, 68-60, 81-72.Sports Related Videospowered by AdSparcRead Next Don’t miss out on the latest news and information. Filipinos turn Taal Volcano ash, plastic trash into bricks PLAY LIST 01:40Filipinos turn Taal Volcano ash, plastic trash into bricks01:32Taal Volcano watch: Island fissures steaming, lake water receding02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respitelast_img read more