Tag: 上海水磨

Oxford study finds immune memory of coronavirus in patient T cells

first_imgProfessor Dong, who led the study, said: “By studying the T cell immune response in depth and breadth, we will begin to build a better understanding of why some individuals develop milder disease, and how we might be able to prevent or treat infections.” Professor Paul Moss of the University of Birmingham, who leads the UK Coronavirus Immunology Consortium, added: “This paper is highly important in the fight against SARS-CoV-2. The team demonstrate that cellular immune responses develop in most people after infection and are particularly strong in those with more severe disease. This provides the foundation for new approaches to assess immunity and also for optimisation of vaccine design”. Study co-lead Professor Graham Ogg, Interim Director of the Medical Research Council Human Immunology Unit, said: “We found that individuals with mild COVID-19 had a different pattern of T cell response when compared to those with more severe infection; this could help provide insights to the nature of immune protection.” He continued that “the research demonstrates the power of bringing together many clinicians and scientists to address a global challenge, and we are extremely grateful to all of those involved, especially the research participants.” He added that “T cells may also be longer lasting than antibodies, and so could offer alternative methods to diagnose whether someone has had a past COVID-19 infection, after antibody levels have waned.” Oxford University researchers have found that infection with coronavirus leads to a significant T cell response. This includes T cell ‘memory’ to “potentially fight future infections”. This paper, published in Nature Immunology, is based on the work of the Medical Research Council Human Immunology Unit and the Oxford Institute of the Chinese Academy of Medical Sciences.center_img It was already clear that infection with coronavirus leads to a B cell antibody response, but previous research had been less perceptive regarding whether coronavirus prompts the production of virus-specific T cells. Antibodies destroy the inciting agents – viruses and bacteria – while T cells latch onto cells in the body which are already diseased. This includes virus-infected cells. The team’s next steps include investigating how long T cellimmune memory lasts and whether this has implications for new diagnostic testsand future treatments. Other scientists across the country were enthused by the new paper. Professor Peter Openshaw from Imperial College London, the Immunology Lead for UK ISARIC, said: “It is exciting to see the speed with which UK scientists can generate such novel findings and the spirit of collaboration that underpins it. T cells are important in clearing the virus and recognise parts of SARS-CoV-2 that are not seen by antibody. The role that they play in disease is not yet fully revealed, but this study provides the tools for studies to be done. This landmark study opens many new areas of work”. Image Credit to National Institute of Allergy andInfectious Diseases / Wikimedia Commons. License: CC-BY-2.0.last_img read more

Fujifilm says significantly boosts capacity for COVID-19 treatment Avigan

first_imgJapan’s Fujifilm said it has expanded manufacturing capacity to “significantly increase” production of its anti-flu drug Avigan that is being tested as a treatment for COVID-19.Fujifilm expects to increase the production of Avigan up to 100,000 treatment courses by July 2020, about 2.5 times more compared to the beginning of March when the company first began its current production run, and then to 300,000 by September, it said in a statement on Wednesday.Fujifilm is allocating additional capacity at its Fujifilm Wako Pure Chemical facility in Japan to produce the ingredients used to make Avigan. The company has also made partnerships with domestic and overseas companies for manufacturing processes and the production of raw ingredients.Fujifilm is conducting clinical trials of Avigan on patients of COVID-19, the disease caused by the novel coronavirus, in Japan and the United States.Topics :last_img read more

“4 The Troops” helps for the holidays

first_img 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREWalnut’s Malik Khouzam voted Southern California Boys Athlete of the Week Galvan began by sending care packages to people she or her friends knew, and the operation then grew to serve thousands of troops per year. “This project has been medicine to my soul,” said Galvan. She said the troops greatly appreciate the service, usually sending e-mails and letters to donors who respond to their requests. The correspondence provides “a connection to home,” Galvan said, and also “helps them remember that people really care.” Galvan said 4 The Troops has been especially rewarding for her recently as she undergoes chemotherapy. She hopes to continue her work with 4 The Troops and praised the support she’s received from soldiers she’s spoken to. Donors are encouraged to stop by American Legion Post 280 at 179 N. Vinedo Ave. in Pasadena to make tax-deductible contributions. The current donation drive ends Dec. 1. Information can be found at www.4thetroops.org or by calling (866) 410-HERO. PASADENA – After several natural disasters have captured the nation’s philanthropic attention, one local charity organization wants to remind people about the needs of American soldiers during the holidays. Pasadena’s “4 The Troops,” a nonprofit organization, collects donations for care packages that it sends to soldiers deployed in Iraq, Afghanistan and other parts of the world. Donations have been low this year. Troops in need of supplies, usually entertainment items such as DVDs and video games, sign up with the organization and make requests, and 4 The Troops then tries to fulfill those requests from donations. It typically sends out between 2,000 and 5,000 care packages per year. The 4 The Troops group was founded in March 2003 by Anne Galvan, and it now has offices in Pasadena and Los Angeles. Galvan, who lives in Diamond Bar, said her brother served in the Air Force during Operation Desert Storm and she was inspired to create the organization after watching footage of the current Iraq war on TV. last_img read more

78 fewer mental health professionals in Northwest than 10 years ago

first_imgThere are 78 fewer professionals working in mental health services across the HSE region CHO1 than ten years ago new figures show.The local HSE Area, which covers counties Donegal, Cavan, Leitrim, Monaghan and Sligo, has seen the number of full-time posts within mental health services being reduced from 1,032 in 2009 down to just 954 as of July this year.Deputy Pearse Doherty said the figures illustrate the complete disregard the government has for people with mental health problems. He added the shocking figures come amidst an ongoing recruitment and retention crisis with some 700 vacancies in mental health services alone across the state.Deputy Doherty said “These figures which reveal that there are today 78 fewer full-time staff employed within local Community based mental health services here in the northwest region compared to the same period ten years ago is beyond comprehension.“As a local elected representative, I am constantly being contacted by families who share stories of loved ones who are being let down by gaps in the service, often citing a lack of community and after hours care and support.“And despite the best efforts of our hard working frontline staff, these latest figures clearly show that local mental health services here in Donegal and neighbouring counties are chronically understaffed and under resourced. “The data illustrates that while for the majority of HSE regions there have been an increase, albeit a modest one, in the number of staff working within mental health services, CHO1 – which includes Donegal – is one of the areas where staffing levels are lower than they were back in 2009.“It’s no surprise that a recent Mental Health Commission report was damning in its criticism of how problems such as poor hygiene within mental health units, as well as inadequate staffing were undermining patients’ rights and called on the government to make significant steps to address these issues.“This is why, prior to the summer recess, Sinn Féin tabled and won support for amendments to a Dáil motion which called on both the government and the HSE to produce a real plan aimed at improving patient care and at providing support to staff and all those working within mental health services.“Our amendments included demands that the post of National Director for Mental Health be reinstated, that an information system for mental health services be developed, and for the government to commit to not implementing a freeze on recruitment or overtime for essential staff.“However, the government continues to drag its heels on taking steps towards improving services for those living with mental health difficulties and – as we’ve seen all too many times before – patients here in Donegal continue to suffer disproportionately due to Fine Gael’s health policies.” 78 fewer mental health professionals in Northwest than 10 years ago was last modified: September 6th, 2019 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)last_img read more

Early Man Studies: Start Over

first_imgAnthropologist Leslea J. Hlusko (U. of Illinois) had some stern advice for her paleoanthropologist colleagues in PNAS1 recently.  Noting that “Competing interpretations of human origins and evolution have recently proliferated despite the accelerated pace of fossil discovery,” she thinks an approach is needed that integrates genetics and development with the search for bones.  She takes issue with three presumptions that can confuse and mislead the interpretation of fossils:Presumption 1: Anatomical Traits are Independent.Genetic studies, on the contrary, have shown that multiple traits can be linked because of pleiotropic effects.  Also, the number of labeled traits may not correspond to the number of genes affecting those traits.Presumption 2: Most Anatomical Traits Are Adaptively Informative.Pleiotropic effects may also blur the interpretation of single traits.  In Lucy, for instance, the genes that shorten fingers may simultaneously shorten toes.  The shortened fingers, therefore, may not be a clue that the animal was spending less time in trees.Presumption 3: Small-Scale Morphological Change Is Almost Always Parsimonious.This is not always the case.  Measurements of trends in enamel thickness on teeth, for instance, appear to have no correlation to sex or tooth size.  Rapid changes can occur with dietary change, not evolution.  “All of this clearly makes the paleontologist’s task of identifying the most phylogenetically informative traits difficult and complex.”She warns bone hunters to recognize that they need to take genetics and development into account.  “The standard response to controversy in paleontology is that more fossils will resolve the issue.”  Not necessarily; “even for species with adequate fossil records, new and different approaches like those suggested here will be necessary.”1Leslea J. Hlusko, “Integrating the genotype and phenotype in hominid paleontology,” Proceedings of the National Academy of Sciences USA, March 2, 2004, vol. 101, no. 9, pp. 2653�2657. Published online before print.This is a revealing article that basically says, “everything you know is wrong, and we hope we can figure out the truth some day by starting over.”  Like so often reported here, it is more admission of ignorance and promises of futureware.  Quote-hunters might find a bonanza in this article.    Not only that, Hlusko points out the tremendous complexity of genetic and developmental mechanisms.  She mentions that more than 250 genes are known to be involved in the development of dentition.  Are we being asked to believe that those genes all evolved by chance, and that they must mutate together to keep an animal having a proper bite?  What if a tooth on the upper jaw mutates, but the one on the lower jaw doesn’t?  Teeth need to match.    Remember how much propaganda the Darwinists got out of one tooth in the case of Nebraska man?  (It turned out to be a pig’s tooth.)  Even today, a debater for evolution claimed that a good anatomist can tell a lot about a creature from a tooth.  But if all you have is a tooth, even if it is the whole tooth, and nothing but the tooth, would it convince a jury?  Not if they read this article first.    Things are not looking good for the pseudoscience of human evolution.  Digging up bones in Africa may be a sport, but interpreting what they mean is often a function of the storytelling ability of the discoverer.  Does hominid dentition tell us anything about human ancestry?  Don’t bite on it.(Visited 20 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

C.A.R.E.S. puts sustainability in the hands of the farmer

first_imgShare Facebook Twitter Google + LinkedIn Pinterest Farmers face public pressure these days to increase their efforts to protect the environment. Given this increased public attention, as well as EPA and local government initiatives, farmers are turning to sustainable farming practices centered on nutrient management.Crop Production Services (CPS) has developed a platform to provide education, seed recommendations, and the technology and nutrients growers need to take a proactive approach to ensure the highest productivity while minimizing environmental impact. The program is called C.A.R.E.S., an acronym for Certified Action Regarding Environmental Stewardship.“C.A.R.E.S. includes the best available farming practices based on the 4Rs and then we tailor those practices to the farm level and field level,” said Steve Emery, Division Manager for CPS in Southern Ohio. “The stewardship practices within the program are both cultural and agronomic and they help the farmer do the right thing for the environment, but C.A.R.E.S. also gives them a voice and a platform to point to and say what they are doing on their particular farm to be sustainable.”C.A.R.E.S. also allows farmers to document their practices while they continue to learn how best to protect the environment and operate a sustainable business, from planting season to harvest.“When we look at seed one of the things that helps a grower qualify within the CPS C.A.R.E.S. program is variable rate seeding,” Emery said. “Those rates are based off of a soil type or a previous year’s history and we can also pull in some satellite imagery to develop those areas of the field that allow us to put more inputs where we can truly maximize yield and back off the seeding rate where that yield potential is lagging.”If this sounds like a program only suited for larger operations, Emery says C.A.R.E.S. can work for any farm.“That’s the beauty of the program is that it is tailored all the way to the farm level,” Emery said. “So every grower, every farm and every field can see a benefit.”Emery said farmers will use the data gathered through C.A.R.E.S. to help make decision on the farm, but that information can also be used for farmers to share their sustainability efforts with neighbors and the community, to show how efforts are being made to protect natural resources, like air, soil and water, in their area.To find out more about the C.A.R.E.S. program, contact your local CPS retailer, or visit cropproductionservicescares.comlast_img read more

Cyclone ‘Bulbul’ to make landfall between West Bengal and Bangladesh coasts

first_imgCyclone ‘Bulbul’, which has intensified into a very severe cyclonic storm, is likely to make landfall between West Bengal and Bangladesh in the early hours of Sunday, bringing in its wake heavy rain and gusts of up to 135 kmph in the coastal areas, the Met department said.The storm might cause damage to kutcha houses, power and communication lines and roads in parts of the state, Regional Met Director G.K. Das said, advising people in vulnerable areas to stay indoors.It might also uproot trees, ruin crops and cause embankment erosion, he warned.According to Mr. Das, Kolkata was expected to experience heavy to very heavy rainfall with gusts of up to 70 km per hour on November 9 and 10.The weatherman said the severe cyclonic storm, which lay centred 600 km south of Kolkata on Friday morning, was expected to intensify further by Saturday and move northwards.“Thereafter, it is very likely to re-curve northeastwards and make landfall between Sagar Islands of West Bengal and Khepupara in Bangladesh across Sunderban delta during the early hours of November 10,” Das said.During landfall, ‘Bulbul’ is “very likely” to be in the ‘severe cyclonic storm’ category with maximum sustained windspeed of 110 to 120 km per hour, gusting up to 135 kmph, the regional Met director said.The weatherman has asked the Bengal administration to suspend fishing activities and ferry boat service on November 9 and 10 in Kolkata, North and South 24 Parganas, Howrah, Hooghly, East and West Midnapore districts.It suggested that coastal hutment dwellers be moved to safer places.The Met department also asked tourists in seaside resort towns along the West Bengal coast not to indulge in any water-based activity from the evening of November 8.According to the IMD, light to moderate rain was likely at many places over the coastal districts of West Bengal on Friday, with heavy rain at one or two areas.The intensity of showers is very likely to increase on November 9 with heavy to very heavy rain at a few places and extremely heavy rain at one or two places in North and South 24 Parganas, East and West Midnapore, Kolkata, Howrah and Hooghly.The weatherman said that gale wind speed reaching 120 to 130 kmph and gusting to 140 kmph was prevailing over westcentral and adjoining eastcentral Bay of Bengal.“The windspeed is very likely to increase gradually to 145 to 155 kmph, with gusts of up to 170 kmph by early hours of November 9,”Mr. Das said.The coastal areas of the state were likely to be hit by 110 to 120 kmph gale wind, with gusts up to 135 kmph from November 9 afternoon, the IMD prediction said.34 NDRF teams in WB, OdishaThe NDRF has stationed a total of 34 teams in West Bengal and Odisha in view of the approaching severe cyclone Bulbul, a senior official said on Friday.Seventeen teams each have been stationed in the two states and the National Disaster Response Force is prepared to tackle any eventuality, NDRF Director General S N Pradhan said here.An NDRF team has about 45 personnel.Mr. Pradhan said out of the total teams in Odisha, six have been deployed while the rest are in reserve. Similarly in West Bengal, 10 teams of the counter-disaster force have been deployed while the rest are on standby.“All preparations have been done and our teams are in touch with the administrative authorities of both West Bengal and Odisha,” he said.The National Crisis Management Committee, headed by Cabinet Secretary Rajiv Gauba, on Friday took stock of the preparedness for rescue and relief operations for ‘Bulbul’, which is likely to hit Odisha and West Bengal.The IMD has said the cyclone, which had developed over Bay of Bengal, has now intensified and is likely to cross the West Bengal coast by early Sunday morning.Heavy-to-extremely heavy rainfall, accompanied by winds reaching up to 110-120kmph and tidal waves up to 1.5 metres, are expected.last_img read more

Video: Johnny Manziel Kicked Out Of Nightclub After Fight

first_imgVideo of Johnny Manziel being tossed out of a night club.Former Texas A&M quarterback Johnny Manziel cannot stay out of the headlines. Friday night, according to TMZ, Manziel was involved in a fight at Jewel Nightclub in Las Vegas just before a Drake performance was scheduled. Manziel was later kicked out of the club for the incident.Here’s more, via TMZ.Witnesses inside Jewel Nightclub at the Aria tell TMZ Johnny was in a VIP booth near the stage Friday night. Drake showed up for a surprise performance and club goers started to push and shove to get up front. Our sources say Johnny got pushed and turned and slugged the club goer.TMZ also obtained video of a small portion of the incident.Manziel appears to be struggling big time right now. Let’s hope he straightens his life out sooner rather than later.last_img read more

Initiatives to Improve Services of Social Security Ministry

first_img Among the initiatives are the construction and improvement of several parish offices, including a new office in Hanover, which will be opened on February 28; and construction of a parish office in St. Ann, which should be completed in the first quarter of 2019/2020. Story Highlights “We are aware that as a service Ministry, we need to ensure that our clients are at the heart of what we do. Many of the initiatives being pursued will bear fruit in the 2019/2020 financial year,” Portfolio Minister, Hon. Shahine Robinson, said at the quarterly press briefing, held on January 30 at the Ministry in Kingston. The Ministry of Labour and Social Security has embarked on a number of initiatives aimed at improving its services.“We are aware that as a service Ministry, we need to ensure that our clients are at the heart of what we do. Many of the initiatives being pursued will bear fruit in the 2019/2020 financial year,” Portfolio Minister, Hon. Shahine Robinson, said at the quarterly press briefing, held on January 30 at the Ministry in Kingston.Among the initiatives are the construction and improvement of several parish offices, including a new office in Hanover, which will be opened on February 28; and construction of a parish office in St. Ann, which should be completed in the first quarter of 2019/2020.Mrs. Robinson said the St. James office is to be completely renovated, and that drawings for the renovation of the Ministry’s Ripon Road offices in Kingston are being finalised and will be put to tender by June.She also noted that the Ministry’s wide-area network (WAN) will be upgraded, using fibre-optic cable.“This might seem like a simple thing, but this upgrade will enable us to move more of our services online, expand the digitisation of files in parishes and reduce the use of paper. The removal of paper files will enable us to become more efficient as a Ministry,” she said.Mrs. Robinson noted that digitisation of National Insurance Scheme (NIS) files commenced in June 2018, and, to date, more than 50,000 files have been digitised. The Ministry of Labour and Social Security has embarked on a number of initiatives aimed at improving its services.last_img read more

AAP hits out at Union Minister Hardeep Singh Puri for his antiDelhi

first_imgNew Delhi: Hitting out at Union Minister Hardeep Singh Puri for his “anti-Delhi” policies, the Aam Aadmi Party Wednesday said a person who has nothing worthwhile to show in his performance as a minister is now venturing into the arena of electoral political analysis. Challenging Puri for an open debate, the AAP said it we will expose the “real face” of BJP and the Union Minister as well as question his anti-Delhi policies in the next seven days. Also Read – After eight years, businessman arrested for kidnap & murder The comments by the AAP comes a day after Puri reportedly slammed Chief Minister Arvind Kejriwal for becoming “desperate” for an alliance. AAP chief spokesperson Saurabh Bharadwaj said Puri need not worry about the Aam Aadmi Party, but rather tell the people of Delhi about his “anti-Delhi approach”. “For next seven days, we will expose the real face of BJP and Mr Puri and question his anti-Delhi policies. We challenge him for a open debate. New political wisdom has dawned on BJP’s Rajya Sabha MP from Uttar Pradesh Hardeep Singh Puri, who was made a minister of state in the Narendra Modi government, 18 months back. Also Read – Two brothers held for snatchings “Puri, who has nothing worthwhile to show in his performance as a minister, is now venturing into the new arena of electoral political analysis,” Bharadwaj said in a statement. Bharadwaj said it is beyond “any reasonable understanding in which capacity Puri is giving his expert comments on the political situation of Delhi, and why is he so worried about the AAP?” The AAP also asked Puri why did the BJP central government’s nominees on the Delhi Metro Board support the “unjustified” Metro fare hike? “What were the instructions of your ministry to the central government nominees on the Metro Board about the Metro fare hike? Why has the Narendra Modi government stalled approval to three routes of Delhi Metro Phase-IV?” he said.last_img read more